Diagnosis of Pulmonary Embolism Using D-Dimer Thresholds Selected According to Clinical Pre-Test Probability

ISTH Academy, Kerstin de Wit, 273910

Development of a Formulation for Oral Delivery of FVIII via a Robotic Pill

ISTH Academy, Gerald Schrenk, 273977

A Test of the GPIbα β-switch Hypothesis for Platelet-type von Willebrand Disease

ISTH Academy, Matthew Auton, 274089

Knockout of von Willebrand Factor in Zebrafish by CRISPR/Cas9 Mutagenesis

ISTH Academy, Pudur Jagadeeswaran, 274121

Welcome and Introduction

ISTH Academy, Chris Barnes, 274975

The Multi-Functional Role of FVIII

ISTH Academy, Johannes Oldenburg, 274976

Emerging Clinical Evidence

ISTH Academy, Ingrid Pabinger-Fasching, 274977

Optimization of Patient Management via WAPPS

ISTH Academy, Alfonso Iorio, 274978

Q&A and Close

ISTH Academy, Session Speakers, 274979

Safety of Dabigatran Etexilate for Secondary Prevention of Venous Thromboembolism in Paediatric Patient

ISTH Academy, Leonardo Brandao, 273755

Efficacy and Safety of Dabigatran Etexilate for Treatment of Venous Thromboembolism in Paediatric Patients - Results of the DIVERSITY Trial

ISTH Academy, Manuela Albisetti, 273756

Novel Single Cell Mechanobiology Approach Reveals an Intermediate State of Integrin αIIbβ3 that Mediates Platelet Aggregation under Blood Flow Disturbance

ISTH Academy, Lining Arnold Ju, 273760

Recombinant Canine and Human FXa-I16LProvide Safe and Efficacious Hemostasis during Major Bleeding Events in Hemophilia A Dogs with High-titer Inhibitory Anti-FVIII Antibodies

ISTH Academy, Timothy Nichols, 273762

Proteomic Analysis Reveals Age-Specific Global Changes in Platelet, Plasma and Endothelial Haemostatic Proteins

ISTH Academy, Conor McCafferty, 273773

The Imbalanced Hepatic Production of PAI1 and tPA Contributes to Decreased Fibrinolysis in Obesity

ISTH Academy, Ze Zheng, 273781

Retrospective Review of Outcomes and Anticoagulation use for Elderly Patients that Present with an Acute Hip Fracture at Three Tertiary Hospitals in Perth, Western Australia

ISTH Academy, Katherine Creeper, 273789

Novel Plasmin Generation Assay Reveals a Plasminogen Activator Inhibitor-1-Independent Mechanism That Contributes to the Hemostatic Imbalance in Experimental Obesity

ISTH Academy, Adam Miszta, 273798

Investigation of the Age-specific in vitro Effect of Bivalirudin in Children Compared to Adults

ISTH Academy, Xavier Busuttil-Crellin, 273805

Investigations of the von Willebrand Factor (VWF) p.Arg273Trp Variant Using Endothelial Colony Forming Cells (ECFCs)

ISTH Academy, Mackenzie Bowman, 273814

Neither a Structured Questionnaire at Pre-anesthesia Visit Nor the Prescription of Routine Hemostatic Tests Have Acceptable Performances to Detect Hemostatic Abnormalities before Surgery

ISTH Academy, Nadine Ajzenberg, 273826

Effect of DOAC Type and DOAC Dose, and Residual DOAC Level on Risk for Perioperative Major Bleeding and Arterial Thromboembolism

ISTH Academy, James Douketis, 273835

Retrospective Analysis of the Clinical Effectiveness of a Reduced Dose of Idarucizumab in Dabigatran Reversal

ISTH Academy, Louisa Stone, 273844

Sodium-calcium Exchanger Reverse Mode is Required for Generation of Procoagulant COAT Platelets

ISTH Academy, Alessandro Aliotta, 273847

FcγRIIa Polymorphisms and Allele-Specific Haplotypes in Heparin-Induced Thrombocytopenia (HIT)

ISTH Academy, Christine Lee, 273868

Extensive Tyrosine Phosphoproteomic Analysis of the CLEC-2 Signalling Cascade in Human Platelets: New Players on the Team

ISTH Academy, Maria Nuñez Barrachina, 273887

Characterization of a Novel GPIbα Knockin Mouse that Lacks the Last 24 Amino Acids of its Intracellular Domain

ISTH Academy, Isabelle Salles-Crawley, 273898

Identification and Characterization of Murine FVIII-producing Cells in vivo

ISTH Academy, Morisada Hayakawa, 273925

The Rare MAST2 Arg89Gln Mutation Causes Venous Thrombosis in a French Family with Unexplained Thrombophilia: The Breizh MAST2 Mutation

ISTH Academy, Pierre Emmanuel Morange, 273927

The Route of FVIII Endocytosis by Antigen-presenting Cells Determines the Pattern of FVIII Peptide-specific T Cells Activation

ISTH Academy, birgit reipert, 273937

TMT-based Temporal Quantitative Phosphoproteome of Human Platelets in Response to Collagen

ISTH Academy, Peng Jiang, 273941

Hepatic Thrombopoietin Gene Silencing Induces Platelet Count Reduction within the Hemostatic Range and Reduces Breast Cancer Progression in MMTV-PyMT Mice

ISTH Academy, Toshiaki Shirai, 273944

Exploring Spontaneous Readthrough over Recurrent F8 Nonsense Mutations: Potential Correlation with Inhibitor Risk?

ISTH Academy, Silvia Lombardi, 273947

Decoding Gα_q Signaling in Platelets

ISTH Academy, Peisong Ma, 273956

Activated Thrombin Activable Fibrinolysis Inhibitor (TAFIa) Regulates Plasmin Generation on Thrombin-activated Platelets

ISTH Academy, Paul Kim, 273964

Comparison of Stroke Incidence in Fontan Patients Receiving Warfarin or Aspirin

ISTH Academy, Chantal Attard, 273989

Increased in vivo Angiogenesis in von Willebrand Factor (VWF)-deficient Mice

ISTH Academy, Soundarya Selvam, 273994

An Engineered Protein Analogous to IL-2, Mutein 24, Decreases the Formation of Factor VIII Inhibitors in Hemophilia Mice Receiving Factor VIII Treatment

ISTH Academy, Alex Chen, 273999

Anti Platelet Antibodies Predict Platelet Desialylation and Apoptosis in ITP

ISTH Academy, Shiying Silvia Zheng, 274001

A Dysbiotic Gut Microbiota Diminishes Short-Chain Fatty Acid Production and Increases Factor VIII Immunogenicity in Haemophilia A Mice

ISTH Academy, Matthew Cormier, 274002

In vivo Enrichment of Genetically Manipulated Platelets for Murine Haemophilia B Gene Therapy

ISTH Academy, Yingyu Chen, 274006

Allele-specific Inhibition of VWF p.Cys1190Tyr in Patient-Derived Endothelial Colony Forming Cells Corrects the von Willebrand Disease Type 2A Phenotype

ISTH Academy, Annika de Jong, 274012

Development and Validation of a Plasma micro-RNAs Profile Associated with Venous Thrombosis

ISTH Academy, José Manuel Soria, 274014

Efficacy and Safety of Prothrombin Complex Concentrate in Patients with Intracranial Bleeding Treated with Factor Xa Inhibitors and Patients Treated with Vitamin K Antagonists

ISTH Academy, Roisin Bavalia, 274015

In vitro and in vivo Amelioration of the von Willebrand Disease Type 2B Phenotype Using an Allele-specific siRNA

ISTH Academy, Annika de Jong, 274017

Generating Plasma Protein Signatures for Murine Venous Thrombosis and Slc44a2 Deficiency Using a Multiplex Targeted Proteomics Approach

ISTH Academy, Julia Tilburg, 274019

High-throughput Immunoprofile Mimotope Variation Analysis in Previously Untreated Patients with Severe Haemophilia A before and after FVIII Exposure

ISTH Academy, Roberta Palla, 274024

Shear Rate Gradients Promote a Bi-phasic Thrombus Formation in a Vwf-dependent Manner

ISTH Academy, Nicolas Receveur, 274034

Platelet-dependent Activation of Thrombin-activatable Fibrinolysis Inhibitor (TAFI)

ISTH Academy, Yuko Suzuki, 274047

Large Gene Deletion in a VWD Patient Impairs VWF Storage in WPBs and Affects Phenotypic Features of Blood Outgrowth Endothelial Cells

ISTH Academy, Hamideh Yadegari, 274055

Targeting Thrombolytics for Thrombotic Thrombocytopenic Purpura

ISTH Academy, Steven de Maat, 274063

Plasma-derived FVIII/VWF Combined with Emicizumab in Hemophilia A Plasma with and without Inhibitor Has a Non-additive Effect on in vitro Thrombin Generation

ISTH Academy, Maria Isabel Bravo, 274071

Clinical Association of Increased Antioxidant Enzymes Levels in Immune Thrombocytopenic Purpura

ISTH Academy, Aisha Arshad, 274072

Immune Phenotyping Predicts Prognosis and Treatment Response in Newly Diagnosed Childhood Immune Thrombocytopenia

ISTH Academy, David Schmidt, 274076

Differential Production of Cytokines in Response to FVIII in Hemophilia Patients Undergoing ITI: A Preliminary Analysis of a Multi-center Longitudinal Study

ISTH Academy, Davide Matino, 274079

Feasibility of a New, Rapid Functional Assay for the Diagnosis of Heparin-induced Thrombocytopenia: A Standardized Flow Cytometry Assay

ISTH Academy, Justine Brodard, 274092

Curating Disease-causing Genes for Bleeding, Thrombotic and Platelet Disorders, and Application to the ThromboGenomics Gene Panel Test

ISTH Academy, Karyn Megy, 274107

Platelet mRNA Splicing Landscape and its Effect on Platelet Activity: An ACCOuNT Consortium Study

ISTH Academy, Kaitlin Garofano, 274130

Antithrombin Activity Levels Below 60% in Children Less than 1 Month of Age Have Implications for Heparin (LMWH) Dosing

ISTH Academy, Irene Regan, 274136

FcγRIIa Polymorphisms and Allele-Specific Haplotypes in Heparin-Induced Thrombocytopenia (HIT)

ISTH Academy, Christine Lee, 275121

In vivo Enrichment of Genetically Manipulated Platelets for Murine Haemophilia B Gene Therapy

ISTH Academy, Yingyu Chen, 275124

Generating Plasma Protein Signatures For Murine Venous Thrombosis and Slc44a2 Deficiency Using a Multiplex Targeted Proteomics Approach

ISTH Academy, Julia Tilburg, 275125

Increased in vivo Angiogenesis in von Willebrand Factor (VWF)-deficient Mice

ISTH Academy, Soundarya Selvam, 275126

Investigations of the von Willebrand Factor (VWF) p.Arg273Trp Variant Using Endothelial Colony Forming Cells (ECFCs)

ISTH Academy, Mackenzie Bowman, 275127

Novel Single Cell Mechanobiology Approach Reveals an Intermediate State of Integrin αIIbβ3 that Mediates Platelet Aggregation under Blood Flow Disturbance

ISTH Academy, Lining Arnold Ju, 275129

Decoding Gαq Signaling in Platelets

ISTH Academy, Peisong Ma, 275132

Immune Thrombosis From a Clinical Perspective

ISTH Academy, Sam Schulman, 275191

Combining Antiplatelet and Anticoagulant Therapy

ISTH Academy, John Eikelboom, 275192

Risk Stratification of Patients with Acute PE: Implications for Home Treatment and Reperfusion Strategies

ISTH Academy, Stefano Barco, 275193

Platelet Microparticles and Inflammatory Diseases

ISTH Academy, Eric Boilard, 275194

Activation and Regulation of the Thrombopoietin Receptor

ISTH Academy, Ian Stuart Hitchcock, 275201

VKA are the Anticoagulant of Choice for Mechanical Valves in Pregnancy (Debate)

ISTH Academy, Claire McLintock, 275203

VKA are the Anticoagulant of Choice for Mechanical Valves in Pregnancy (Debate)

ISTH Academy, Dominica Zentner, 275204

Diagnosis of PE in Pregnancy

ISTH Academy, Grégoire Le Gal, 275205

Spatiotemporal Regulation of Plasminogen Activation and its Disruption

ISTH Academy, Tetsumei Urano, 275208

Fibrin/ogen Structure as a Potential Therapeutic Target

ISTH Academy, Alisa Wolberg, 275209

ADAMTS13 and VWF in TTP

ISTH Academy, José López, 275210

Modifiers and Genetics of VWF

ISTH Academy, Jill Johnsen, 275212

Development of a laser-induced thrombosis model with improved reproducibility allows detailed analysis of dose-response effects of antithrombotic drugs

ISTH Academy, PIa Larsson, 263797

Pathophysiological implications of differential coagulotoxic effects of Bitis viper snake venoms

ISTH Academy, Nicholas Youngman, 263815

Mechanism Of Activation Of The Intrinsic Pathway of Coagulation By Microvesicles Isolated From Red Cell Concentrates

ISTH Academy, Anton Ilich, 263833

Intra-assay reproducibility of a precalibrated liquid Clauss fibrinogen assay

ISTH Academy, Audrey Carlo, 263850

Thrombin-cleaved Osteopontin Enhances B16 Melanoma Growth

ISTH Academy, John Morser, 263868

Chest wall haemophilic pseudo tumour in a patient with severe Haemophilia A with inhibitor: A case report

ISTH Academy, Melanie Jackson, 263884

Ideal Body Weight Is Proven Most Reliable to Dose Factor VIII Concentrate in Overweight and Obese Hemophilia A Patients

ISTH Academy, Iris Van Moort, 263900

The rate of factor VIII inhibitors and mutation profile in Polish previously untreated patients (PUPs) on prophylaxis with octocog-alfa

ISTH Academy, Andrzej Koltan, 263916

The first Chinese hemophilia individualized prophylaxis study (CHIPS) : Improvement in Health-Related Quality of Life (HRQoL) CHO-KLAT scores in boys with severe hemophilia A in China

ISTH Academy, Runhui Wu, 263933

CONGENITAL FACTOR XI DEFICIENCY, INHIBITOR AND CLOT FORMATION

ISTH Academy, Erica Scalambrino, 263950

DELPHI expert consensus statements on clinical evaluation of bleeds in patients with acquired haemophilia

ISTH Academy, Andreas Tiede, 263966

Effect of pathologic flow on von Willebrand factor cleavage by ADAMTS13

ISTH Academy, Maria Bortot, 263983

Association of easy bruising with female gender: a prospective cohort study

ISTH Academy, Michael Nagler, 263999

A Qualitative Analysis on Patient Understanding with Anticoagulation Use & Indication and the Effect of Nurse Practitioner Led Patient Education

ISTH Academy, Laurie Sardo, 264018

Acquired von Willebrand syndrome (aVWS) - a complication in pediatric patients with congenital heart diseases

ISTH Academy, Ivonne Wieland, 264036

Highly discordant laboratory-based aspirin resistance rates after pediatric organ transplantation may reflect significant cyclooxygenase 1-independent thromboxane production postoperatively

ISTH Academy, Lori Luchtman-Jones, 264052

A Retrospective Review of Antithrombotic Therapy in Paediatric Patients with Moyamoya Disease

ISTH Academy, Nadia Poci, 264068

Analysis of Stroke in Neonates and Children: Single Center Experience

ISTH Academy, Hale Ören, 264085

Effective and well tolarated treatment with a direct oral anticoagulant in a young patient with the vena cava inferior agenesis and a deep vein thrombosis

ISTH Academy, Tomas Kuhn, 264102

Bleeding phenotype of patients with congenital platelet defects

ISTH Academy, Rolf Urbanus, 264119

MYH9 Disorders in Thailand: Pediatric Case Series from Thai Macrothrombocytopenia Study Group

ISTH Academy, Rungrote Natesirinilkul, 264135

Post-translational polymodification of the C-terminal tail of TubB1 regulates motor protein activity in platelet production and function

ISTH Academy, Neil Morgan, 264152

Variation of platelet dependent thrombin generation in phenotypes of acute venous thromboembolism

ISTH Academy, Marina Panova-Noeva, 264169