PB0184 Ultrasound Mediated Delivery of CRISPR/Cas9 Plasmid in Hemophilia A Mice Shows Therapeutic levels of FVIII Following NHEJ Gene Editing

ISTH Academy, Faculty / Presenters, 407029

PB0182 Development of a Non-Viral Gene Therapy Approach for Severe Bleeding Disorders

ISTH Academy, Faculty / Presenters, 407030

PB0703 Successful Management of Hemarthrosis in a Patient with Severe Hemophilia A with an Inhibitor, on Emicizumab

ISTH Academy, Faculty / Presenters, 407031

PB0704 Clinical Approach and Monitoring Treatment of Menorrhagia with PBAC (Pictorial Blood Loss Assessment Chart) in 20 VWD Patients

ISTH Academy, Faculty / Presenters, 407032

PB0702 Every Minute Counts: “Door to Factor” Issue Times

ISTH Academy, Faculty / Presenters, 407033

PB0700 FXI Inhibitor Safety in Hemophilia Patients: Computational Prediction of Thrombin Generation

ISTH Academy, Faculty / Presenters, 407034

PB0698 Determinants of Desmopressin Response in Bleeding Disorders: a Systematic Review and Meta-Analysis

ISTH Academy, Faculty / Presenters, 407035

PB0699 Idarucizumab for Dabigatran Reversal: A Systematic Review and Meta-Analysis of Indications and Outcomes

ISTH Academy, Faculty / Presenters, 407036

PB0697 To Test or Not to Test: Do All Individuals with Non-Severe Hemophilia A Need DDAVP Response Testing?

ISTH Academy, Faculty / Presenters, 407037

PB0695 Comparison of Platelet Quality and Hemostatic Function Across Apheresis Collection Platforms

ISTH Academy, Faculty / Presenters, 407038

PB0696 Management of Bleeding in People with Hemophilia A on Prophylaxis with Emicizumab in Emergency Situations: Recommendations from a Spanish Expert Panel

ISTH Academy, Faculty / Presenters, 407039

PB0694 A Chemiluminescent-Based Multiparameter Platform for Simultaneous Measurement of Factor VIII Activity and Thrombin Generation

ISTH Academy, Faculty / Presenters, 407040

PB0693 Efficacy and Safety of Eptacog Beta (Recombinant Activated FVII) in Patients with Hemophilia A or B with Inhibitors According to Time to Initial Infusion: A Post-Hoc Analysis from PERSEPT-1

ISTH Academy, Faculty / Presenters, 407041

PB1314 Risk Assessing Medical Inpatients for Bleeding Events: The Medical Inpatients Thrombosis and Hemostasis (MITH) Study

ISTH Academy, Faculty / Presenters, 407042

PB1312 “The Doctor Says So” - Patient Values and Preferences Regarding Resumption of Oral Anticoagulation after Gastrointestinal Bleeding

ISTH Academy, Faculty / Presenters, 407043

PB1313 Factor V as Adjunct to Fibrinogen and Prothrombin Complex Concentrate in an In Vitro Model of Combined Severe Trauma-Induced Coagulopathy and Rivaroxaban Anticoagulation

ISTH Academy, Faculty / Presenters, 407044

PB1310 Urgent Reversal of DOAC Anticoagulant Effect with Prothrombin Complex Concentrate: Experience in Mexico

ISTH Academy, Faculty / Presenters, 407045

PB1331 New Paradigm in the Treatment of Hemophilia B: Spanish Real-Life Experience with rIX-FP

ISTH Academy, Faculty / Presenters, 407046

PB1329 Retrospective Study of the Effectiveness and Safety of the Use of rIX- FP in Patients with Haemophilia B. Experience of Four Centres in the Region of Castilla y León

ISTH Academy, Faculty / Presenters, 407047

PB1327 Bioequivalence of a Generic Version of rFVIIa (Aryoseven) as Compared to the Branded Version of rFVIIa (Novoseven)

ISTH Academy, Faculty / Presenters, 407048

PB1326 Real-World Data on Correlation between Emicizumab Plasma Levels, Ex-Vivo Procoagulant Profile and Spontaneous Joint Annualized Bleeding Rate of Patients on Emicizumab Prophylaxis

ISTH Academy, Faculty / Presenters, 407049

PB1325 A Novel Recombinant Factor VII D60A May Potentially Reduce the Risk of Thrombotic Complications

ISTH Academy, Faculty / Presenters, 407050

PB1324 Evaluation of the Analytical Performance of a Modified One-Stage FVIII Assay for the Plasmatic Quantification of Emicizumab

ISTH Academy, Faculty / Presenters, 407051

PB1320 A Phase 1 Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MG1113 in Healthy Subjects and Hemophilia Patients

ISTH Academy, Faculty / Presenters, 407052

PB1321 Efficacy/Effectiveness and Safety of Emicizumab Prophylaxis in the Treatment of Hemophilia A: A Systematic Review with Meta-Analysis

ISTH Academy, Faculty / Presenters, 407053

PB1322 Emicizumab Wastage Estimation for Treating People with Hemophilia A and Inhibitors who Failed Immune Tolerance Induction According to the Current Brazilian Public Health Protocol

ISTH Academy, Faculty / Presenters, 407054

PB1323 Impact on Thrombin Generation of Direct Oral Anticoagulants in a FVIII Deficient Plasma Spiked with Emicizumab and Human FVIII

ISTH Academy, Faculty / Presenters, 407055

PB1319 Efficacy, Safety and Satisfaction of Using Emicizumab in Hemophilia A Patients without Factor VIII Inhibitors: An Integrative Review

ISTH Academy, Faculty / Presenters, 407056

PB1317 Assessment of the Combined Effects of Emicizumab and Fitusiran with In Vitro Spiking of Emicizumab and Simulated Fitusiran into Factor VIII Deficient Plasma Using Thrombin Generation Assay

ISTH Academy, Faculty / Presenters, 407057

PB1316 Impact of Synonymous Gene Recoding on ADAMTS13

ISTH Academy, Faculty / Presenters, 407058

PB1315 Weight-Band Dosing with Mim8: Using Modelling to Support a Streamlined Approach to Haemophilia A Treatment

ISTH Academy, Faculty / Presenters, 407059

PB0193 Financial Impact of Switching to Emicizumab from Conventional Haemostatic Agents in Acquired Haemophilia A

ISTH Academy, Faculty / Presenters, 407060

PB0192 Novel Patient-Directed Learning in the Era of Novel Therapies

ISTH Academy, Faculty / Presenters, 407061

PB1311 Prophylactic Efficacy of VGA039, An Anti-Protein S Monoclonal Antibody, In A Novel Non-Human Primate Model of Acquired Von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407062

PB0242 Epistaxis in a Patient with Glanzmann Thrombasthenia : About a Strasbourg Case Revealing an Endonasal Tumor

ISTH Academy, Faculty / Presenters, 407063

PB0240 Possible Autoimmune Acquired Factor 13 Deficiency : Tailoring Management in a Resource Constrained Setting in India, ACase Report

ISTH Academy, Faculty / Presenters, 407064

PB0236 Bleeding Episode during a Long-Term Anticoagulation with Direct Oral Anticoagulant: An Unusual Revelation of a Severe Factor V Deficiency

ISTH Academy, Faculty / Presenters, 407065

PB0239 Hereditary Coagulation Factor FVII Deficiency Caused by Compound Heterozygous Mutation

ISTH Academy, Faculty / Presenters, 407066

PB0237 Inhibitor in Congenital FXI Deficiency

ISTH Academy, Faculty / Presenters, 407067

PB0238 Prospective, Phase III Study of the Efficacy, Safety, and Pharmacokinetics of a Human Antithrombin III Concentrate in Congenital Antithrombin Deficiency during Surgery or Childbirth

ISTH Academy, Faculty / Presenters, 407068

PB0234 Comprehensive Evaluation of Coagulation and Fibrinolysis Parameters in Patients with Congenital Factor XIII Deficiency in Pakistan: Case Control Study

ISTH Academy, Faculty / Presenters, 407069

PB0235 Phase 3 Study of the Efficacy, Pharmacokinetics, Immunogenicity and Safety of von Willebrand Factor/Factor VIII Concentrate in Patients with Severe von Willebrand Disease under 6 Years of Age

ISTH Academy, Faculty / Presenters, 407070

PB0228 A Prospective, Observational Study of Bleeding and Quality of Life in Patients with Glanzmann Thrombasthenia in the United Kingdom: A First Report

ISTH Academy, Faculty / Presenters, 407071

PB0233 Von Willebrand Disease in the East Mediterranean Region: Current Situation and Gaps

ISTH Academy, Faculty / Presenters, 407072

PB0229 Designing the Ryplazim® (Plasminogen, Human-tvmh) Arm of Athn Transends: Safety and Effectiveness in People with Plasminogen Deficiency

ISTH Academy, Faculty / Presenters, 407073

PB0230 First Insight into the Presurgical APTT Determination Practice in Nigeria through a Nationwide Explorative Survey

ISTH Academy, Faculty / Presenters, 407074

PB0231 Liver Transplant Complicated by Reperfusion Injury in a Child with Severe Factor V Deficiency

ISTH Academy, Faculty / Presenters, 407075

PB0226 Bleeding and Clotting in the Same Patient: A Case of Factor XI Deficiency and Thrombosis

ISTH Academy, Faculty / Presenters, 407076

PB0227 Symptomatic Factor X Deficiency in a Single Family with a Genetic Mutation Previously Reported as of Uncertain Significance

ISTH Academy, Faculty / Presenters, 407077

PB0222 A Novel c.952G>T Mutation in the FGG Gene Exon 8 Causing Hypodysfibrinogenemia

ISTH Academy, Faculty / Presenters, 407078

PB0224 Effective Management of Surgical Procedures of Inherited FVII Deficient Patients - 15 Years Experience at University Hospital in Ostrava

ISTH Academy, Faculty / Presenters, 407079

PB0225 Evaluation of Real-World Treatment Patterns and Outcomes in Patients with Von Willebrand Disease Treated Prophylactically with recombinant Von Willebrand Factor in the United States: Interim Analysis

ISTH Academy, Faculty / Presenters, 407080

PB0221 Clinical Heterogeneity of Congenital Dysfibrinogenemia within ATwo- Generation Family in Brazil

ISTH Academy, Faculty / Presenters, 407081

PB0220 Clinical Presentation and Bleeding Severity in Women with Autosomal Inherited Bleeding Disorders and Hemophilia Carriers: Real-Life Data from the Spanish Registry

ISTH Academy, Faculty / Presenters, 407082

PB0215 Assessment of Global Hemostatic Assay by ROTEM in 63 Patients with Congenital Dysfibrinogenemia

ISTH Academy, Faculty / Presenters, 407083

PB0216 Cancer in Patients with Bleeding Disorders: A French Monocentric Retrospective Study

ISTH Academy, Faculty / Presenters, 407084

PB0218 Trisomy X Conferring Moderate Hemophilia A by Extremely Skewed X-Chromosome Inactivation

ISTH Academy, Faculty / Presenters, 407085

PB0219 Utility of ACMG Classification to Support Interpretation of Molecular Genetic Test Results in Patients with FVII Deficiency

ISTH Academy, Faculty / Presenters, 407086

PB0213 Efanesoctocog Alfa vs. Standard Half-Life (Octocog Alfa) FVIII Therapies for Prophylaxis in Adolescents and Adults with Severe Hemophilia A: A Matching-Adjusted Indirect Comparison and Meta-Analysis

ISTH Academy, Faculty / Presenters, 407087

PB0214 Evaluation of Innovative Laboratory Tests to Predict a Thrombotic Phenotype in a Family with Dysfibrinogenemia and a Novel FGG Mutation

ISTH Academy, Faculty / Presenters, 407088

PB0212 Patient with Spontaneous and Severe Bleeding Episodes Diagnosed of Vascular Ehlers-Danlos Syndrome with a De Novo Pathogenic Variant

ISTH Academy, Faculty / Presenters, 407089

PB0209 Clinical Manifestations of Patients with Congenital Dysfibrinogenemia with the Most Common Hotspot Mutation in FGA Gene p.Arg35His

ISTH Academy, Faculty / Presenters, 407090

PB0210 Heterozygous Structural Variation Mimicking Homozygous Substitution in MCFD2 in a French Patient with Combined Factor V and Factor VIII Deficiency

ISTH Academy, Faculty / Presenters, 407091

PB0211 The Utilities of Multiple Genetic Analyses for Rare Coagulation Deficiencies and Rare Bleeding Disorders

ISTH Academy, Faculty / Presenters, 407092

PB0208 Spleen Rupture in Afibrinogenemia: Hemorrhagic or Thrombotic

ISTH Academy, Faculty / Presenters, 407093

PB0203 Altered Bleeding Phenotype in Patients with Co-inheritance of Genetic Variants in Thrombosis and Hemostases Genes in Rare Bleeding Disorders

ISTH Academy, Faculty / Presenters, 407094

PB0204 Correlation Between the Clinical Phenotype and Genotype Profiles in Children with Congenital Factor VII Deficiency

ISTH Academy, Faculty / Presenters, 407095

PB0205 High Prevalence of Heavy Menstrual Bleeding in Women with Rare Bleeding Disorders in the Netherlands: Retrospective Data from the RBiN Study

ISTH Academy, Faculty / Presenters, 407096

PB0206 Isolated Prolongation of APTT with Abnormal Bleeding Phenotype due to Intrinsic Tenase Defect - A Case Series

ISTH Academy, Faculty / Presenters, 407097

PB0207 Joint Bleeding and Joint Evaluation in Von Willebrand Disease Assessed Using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) Score

ISTH Academy, Faculty / Presenters, 407098

PB0201 Efanesoctocog Alfa Versus Extended Half-Life Factor VIII Therapies for Prophylaxis in Adolescents and Adults with Severe Hemophilia A: A Matching-Adjusted Indirect Comparison and Meta-Analysis

ISTH Academy, Faculty / Presenters, 407099

PB0202 The Impact of Iron Deficiency Anemia on Activation of Coagulation in Hereditary Hemorrhagic Telangiectaisa

ISTH Academy, Faculty / Presenters, 407100

PB0196 Concizumab Enhances Thrombin Generation Potential in Plasma from Patients with FV-Amsterdam

ISTH Academy, Faculty / Presenters, 407101

PB0199 Type 2B Von Willebrand Disease - 30 Years of Experience in a Portuguese Reference Centre

ISTH Academy, Faculty / Presenters, 407102

PB0197 Efficacy of Adjusted Weight-Based Dosing of DDAVP in Type 1 von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407103

PB0195 Efanesoctocog Alfa Versus Emicizumab in the Prophylactic Treatment of Adolescents and Adults with Severe Hemophilia A without Inhibitors: A Matching-Adjusted Indirect Comparison

ISTH Academy, Faculty / Presenters, 407104

PB0194 Comparison of Intraindividual Bleeding Outcomes Pre- and Post- Emicizumab in Australian Adults and Children with Haemophilia A with and without Inhibitors: A Nationwide Real-World Experience

ISTH Academy, Faculty / Presenters, 407105

PB0716 Cancer Cell Cluster in Carcinomatosis Associated with Fibrin Fiber

ISTH Academy, Faculty / Presenters, 407106

PB0717 Urological Cancer Patients Display an Increase in Markers of Hypercoagulability and Inflammation

ISTH Academy, Faculty / Presenters, 407107

PB0712 Establishment of Mouse Xenograft and Allograft Models of Acute Promyelocytic Leukemia and Role of Tissue Factor in the Activation of Coagulation

ISTH Academy, Faculty / Presenters, 407108

PB0715 H3 Alters the Behavior of Endothelial Cells In Vitro

ISTH Academy, Faculty / Presenters, 407109

PB0713 Increased Tissue Factor mRNA Expression is Associated with High Plasma Levels of Activated Factor VII-Antithrombin Complex and Predicts Mortality in Primary Liver Cancer

ISTH Academy, Faculty / Presenters, 407110

PB0711 Increased Levels of NETosis Biomarkers in High-Grade Serous Ovarian Cancer Patients' Biofluids: Potential Role in Disease Diagnosis and Management

ISTH Academy, Faculty / Presenters, 407111

PB0710 Evaluation of the Feasibility and Safety of the Long-Term Expression of Hemopexin using a Viral (AAV8) Vector in an Animal Model of Sickle Cell Anemia

ISTH Academy, Faculty / Presenters, 407112

PB0709 Thrombin Generation (TG) and D-Dimer Significantly Predict Early-Disease Recurrence (E-DR) in High-Risk Breast Cancer

ISTH Academy, Faculty / Presenters, 407113

PB0708 The Tissue Factor/Thrombin Axis Limits Spontaneous Lymphatic Metastasis in Mice

ISTH Academy, Faculty / Presenters, 407114

PB0707 Neutrophil Extracellular Traps Promote Cancer-Associated Inflammation and Myocardial Stress

ISTH Academy, Faculty / Presenters, 407115

PB0705 Pharmacological Inhibition of Coagulation Factor XI Reduces Thromboinflammation in a Nonhuman Primate Model of Early Atherosclerosis

ISTH Academy, Faculty / Presenters, 407116

PB0706 Mechanism by which Coagulation Factor XI Regulates Endothelial Cell Permeability and Barrier Function In Vitro and In Vivo

ISTH Academy, Faculty / Presenters, 407117

PB0721 Continuing Education Enhances Interprofessional Team Members' Ability to Care for Patients with Paroxysmal Nocturnal Hemoglobinuria

ISTH Academy, Faculty / Presenters, 407118

PB0722 Resolution of Hemolysis in a Patient with PNH Treated with Pegcetacoplan

ISTH Academy, Faculty / Presenters, 407119

PB0719 Assessment of Coagulation Activation using Thrombin Generation Assay in Newly Diagnosed Acute Myeloid Leukemia

ISTH Academy, Faculty / Presenters, 407120

PB0718 Complement Inhibition Reduces Fibrin Formation and Platelet Activation during Haemostasis in a Microfluidic Bleeding Model

ISTH Academy, Faculty / Presenters, 407121

PB0728 Models for In Vitro Investigation of Neutrophil Activation

ISTH Academy, Faculty / Presenters, 407122

PB0729 Thrombophilia in Patients with Acute Viral Infections of the Respiratory Tract

ISTH Academy, Faculty / Presenters, 407123

PB0727 The Role of Thrombin and Thrombin Signaling in Chronic LCMV Infection

ISTH Academy, Faculty / Presenters, 407124

PB0725 Tissue Factor on Human Immunodeficiency Virus and Dengue Virus as the Molecular Basis for Hemostatic Pathology

ISTH Academy, Faculty / Presenters, 407125

PB0726 Plasminogen is Crucial for Early Phase Echinococcus Multilocularis Infection But Not for Alveolar Echinococcosis Progression

ISTH Academy, Faculty / Presenters, 407126

PB0723 Protease-Activated Receptor 4 Differentially Modulates TLR3- Dependent Responses In Vitro and In Vivo

ISTH Academy, Faculty / Presenters, 407127

PB0724 TF-FVIIa-PAR2-β-Arrestin Signaling Regulates Monocyte/ Macrophage Responses to Double Stranded RNA

ISTH Academy, Faculty / Presenters, 407128