ISTH Academy

Create Account Sign In
Fibrin Formation and Fibrinolysis Testing in Research
  • 14:00 - 15:00 UTC
  • 10:00 - 11:00 ET (US & Canada)
  • 16:00 - 17:00 CEST (Central Europe)
  • 22:00 - 23:00 HKT (Singapore & Hong Kong)

Session Description
This webinar will feature talks by Dr. Fraser Macrae and Dr. Valerie Tutwiler discussing fibrin formation and fibrinolysis testing in research.

Event Outline:

  • Introduction by Tirsa van Duijl, Ph.D.
  • Microscopy approaches to study fibrin by Fraser Macrae, Ph.D. (20 minutes)
  • In vitro assays to study fibrin formation and FXIII crosslinking by Valerie Tutwiler, Ph.D. (20 minutes)
  • Q&A with audience (15 minutes)

Learning Objectives

Microscopy Approaches to Study Fibrin

  • Understand why we study changes in fibrin clot structure
  • Understand how multiple microscopy methods can be used to investigate fibrin clot structure

In vitro assays to study fibrin formation and FXIII crosslinking

  • Review techniques that can be utilized to assess dynamic changes in clo formation/dissolution
  • Determine the best technique for looking at changes in clotting kinetics and structure

Tirsa van Duijl, Ph.D.
Sanquin Research
Amsterdam, North Holland

Fraser Macrae, Ph.D.
LIGHT Labs, Clarendon Way
Leeds, England
United Kingdom

Valerie Tutwiler, Ph.D.
Rutgers University
Piscataway, New Jersey
United States

Upon completion of this activity, participants should be able to:
  • Describe cardinal features in the presentation of TTP
  • Distinguish between TTP and other disorders of thrombocytopenia
  • Identify appropriate clinical steps for patients with suspected TTP

Activity Title: A Hematologic Emergency: Would You Miss iTTP?
Topic: immune-mediated thrombotic thrombocytopenic purpura (aTTP/iTTP)
Accreditation Type: Physicians—Maximum of 1.0 AMA PRA Category 1 Credit(s)™
Nurses—1.0 contact hours of nursing continuing professional development credit
PAs—maximum of 1.0 AAPA Category 1 CME credits 
Release Date: August 4, 2023
Expiration Date: August 3, 2024
Estimated Time to Complete Activity: 1.0 hour


There are no fees for participating and receiving credit for this activity. Successful completion is achieved by reviewing the CE information, completing the pre-test, completing the activity, and completing the post-test and evaluation form. A score of at least 75% on the posttest is required to successfully complete this activity. The participant may take the test until successfully passed.

Credit fulfillment:
If you are requesting AMA credits, ANCC credits, or a certificate of participation, your certificate will be available for download.

Technical Requirements
This site and its activities are best viewed using the latest versions of the Chrome, Edge, Firefox, and Safari browsers.

Additionally, this site and its activities are best viewed using the latest operating system for your device.


This educational activity is intended for physicians and advanced practice professionals (APPs), including nurse practitioners and PAs who specialize in hematology, emergency medicine, critical care, nephrology, neurology, obstetrics, primary care, and other specialties who treat patients with hematologic emergencies.

This activity is designed to provide clinicians with education on how to recognize and diagnose iTTP and provide education on the management of acute episodes of iTTP, including the risk of relapse and strategies for multidisciplinary management with clinical colleagues.

The France Foundation and ISTH present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, ISTH, and the commercial supporter(s) assume no liability for the information herein.


Spero Cataland, MD
Professor of Internal Medicine
Division of Hematology
Ohio State University
Columbus, OH

Nathan Nielsen, MD, MSc, FCCM
Associate Professor
Division of Pulmonary Critical Care and Sleep Medicine
University of New Mexico School of Medicine
Albuquerque, NM

Marie Ann Scully, MBE, BSc (Hons), MBBS, MRCP, FRCPath
Professor of Hemostasis and Thrombosis
Department of Hematology
University College London Hospitals
London, UK

Learning Objectives
  • How to prepare for your oral presentation: creating your outline
  • How to optimally utilize PowerPoint
  • How to develop your "speech" to go with your slides
  • Tips and Tricks for public speaking

BJ Ramsay
Wellington Regional Hospital
Wellington, New Zealand

Julie Van Orne
Cook Children's Medical Center
Fort Worth, TX
United States


We found no results for your search. Please change or remove at least one filter to broaden your search.

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies