Challenges in management of women with type 2B von Willebrand disease during pregnancy and postpartum: evidence from literature and data from International Registry and Physicians Survey- communication from the SSC of the ISTH: comment from Comerford et al.

ISTH Academy, Maeve Crowley, 404872

“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al

ISTH Academy, Faculty / Presenters, 404873

“C1-inhibitor levels and venous thromboembolism: results from a Mendelian randomization study”: reply

ISTH Academy, Faculty / Presenters, 404874

“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: comment from Tanaka et al.

ISTH Academy, Faculty / Presenters, 404875

“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply

ISTH Academy, , 404876

ISTH News and Updates: Join the ISTH Today

ISTH Academy, Faculty / Presenters, 404877

LB 01.1 Efanesoctocog Alfa Prophylaxis for Previously Treated Patients <12 Years of Age with Severe Hemophilia A

ISTH Academy, Faculty / Presenters, 406097

LB 01.2 Emicizumab Prophylaxis Instead of Immunosuppressive Therapy in Patients with Acquired Hemophilia A (AHA)

ISTH Academy, Faculty / Presenters, 406098

LB 01.3 Factor XIII 24-Hour Trajectory Analysis in Severely Injured Patients: Post-hoc Analysis of the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Study

ISTH Academy, Faculty / Presenters, 406099

LB 01.4 Rare Germline Loss of Function Variants in SERPINH1 (HSP47) are Associated with Increased Risk of Thrombosis

ISTH Academy, Faculty / Presenters, 406100

LB 01.5 Effect of the P-selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial

ISTH Academy, Faculty / Presenters, 406101

LB 02.1 Extending Venous Thromboembolism Secondary Prevention with Apixaban in Cancer Patients. The EVE Trial

ISTH Academy, Faculty / Presenters, 406102

LB 02.2 Prevention of Symptomatic Venous Thromboembolism with LowMolecular-Weight Heparin in Hospitalized Older Adult Medical Patients: A Randomized Placebo-Controlled Trial

ISTH Academy, Faculty / Presenters, 406103

LB 02.3 Targeted Thromboprophylaxis in Patients with Lower Limb Trauma Requiring Immobilization : Stepped Wedge Randomized Trial

ISTH Academy, Faculty / Presenters, 406104

LB 02.4 Anti-Platelet Factor 4 Induced Immunothrombosis Independent of Heparin or Vaccination

ISTH Academy, Faculty / Presenters, 406105

LB 02.5 Distinct Antibody Groups in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) and Their Clinical Implications

ISTH Academy, Faculty / Presenters, 406106

OC 16.1 The Role of Endothelial Glycogen Synthase Kinase (GSK)-3α in Hyperglycemia-Induced Endothelial Activation and Atherosclerosis

ISTH Academy, Faculty / Presenters, 406107

OC 74.5 Safety Outcomes of Oral Anticoagulant Therapy in Patients with Atrial Fibrillation and Chronic Kidney Disease

ISTH Academy, Faculty / Presenters, 406108

OC 74.2 Evaluation of Stroke Risk Scores in Patients with Atrial Fibrillation and Active Cancer

ISTH Academy, Faculty / Presenters, 406109

OC 74.1 Circulating Biomarkers and Mortality in Atrial Fibrillation: The Reasons for Geographic and Racial Differences in Stroke Study

ISTH Academy, Faculty / Presenters, 406110

OC 76.1 Chadox1 Exposure-Induced Neutrophil-Activating Peptide 2 (NAP2) Antibodies: Murine-Based Insights into the Pathogenesis of Thrombosis with Thrombocytopenia Syndrome (TTS)

ISTH Academy, Faculty / Presenters, 406157

OC 22.4 SARS-CoV-2 Protein ORF3a Promotes Release of Procoagulant Tissue Factor-Positive Extracellular Vesicles

ISTH Academy, Faculty / Presenters, 406158

OC 76.2 PAD4-mediated NETosis in ChAdOx1 Vaccine-Induced Thrombosis

ISTH Academy, Faculty / Presenters, 406159

OC 22.2 Endothelial Activation and Von Willebrand Factor Role in COVID-19- Associated Coagulopathy

ISTH Academy, Faculty / Presenters, 406160

OC 22.3 Monocytes and Macrophages Promote Increased Tissue Factor/Factor VIIa-Dependent Procoagulant Activity in Response to the SARS-CoV-2 Spike Protein

ISTH Academy, Faculty / Presenters, 406161

OC 22.1 Proteome and Phosphoproteome Analyses of SARS-CoV-2 Infected Humanized ACE2 Mice Platelets Revealed Reprogramming of Platelets from Early Hyperreactive to Late Antiviral Phenotypes

ISTH Academy, Faculty / Presenters, 406162

OC 76.4 Elevation of Antiphospholipid Antibody Titers Following Vaccination with SARS-CoV-2 mRNA in Patients with Antiphospholipid Syndrome and/or Systemic Lupus Erythematosus

ISTH Academy, Faculty / Presenters, 406163

OC 76.5 Head-to-head Comparison of Four COVID-19 Vaccines on Platelet Activation, Coagulation and Inflammation. the TREASURE Study

ISTH Academy, Faculty / Presenters, 406164

OC 29.2 The Impact of Pulmonary Embolism on the Long-Term Health Outcomes of COVID-19

ISTH Academy, Faculty / Presenters, 406165

OC 76.3 SARS-CoV-2 Vaccination and Risk of Venous Thrombosis – Case Control Study on Routine Care Data from Dutch General Practitioners

ISTH Academy, Faculty / Presenters, 406166

OC 05.1 Impact of Low Molecular Weight Heparin (LMWH) on SARS-CoV2 Infection: HEPARIN-SARS-CoV2 Clinical Trial

ISTH Academy, Faculty / Presenters, 406167

OC 05.4 Defective Nitric Oxide Production and Increased Reactive Oxygen Species Generation by Platelets from COVID-19 Patients

ISTH Academy, Faculty / Presenters, 406168

OC 05.2 Impact of Heparin on Disease State Transition in Hospitalized, Non-Critically Ill Patients with COVID-19; Secondary Analysis of an International Multi-Platform RCT

ISTH Academy, Faculty / Presenters, 406169

OC 05.3 Incidence and Risk Factors for Venous Thromboembolism in Hospitalized Patients Across Three Major COVID-19 Variants in an Asian Cohort

ISTH Academy, Faculty / Presenters, 406170

OC 29.3 CD147 Plasma Levels in Hospitalised Patients with Covid-19 Pneumonia Predict Illness Severity and In-Hospital Mortality

ISTH Academy, Faculty / Presenters, 406171

OC 29.5 Outcomes of COVID-19 in Persons with Hemophilia: A Propensity ScoreMatched Cohort Study froma US-BasedNational COVIDRegistry

ISTH Academy, Faculty / Presenters, 406172

OC 29.1 Long-Term Outcomes of COVID-19 Associated Venous Thromboembolism (VTE)

ISTH Academy, Faculty / Presenters, 406173

OC 29.4 Impact of Symptom Duration on Clinical Outcomes in Hospitalized, Non-Critically Ill Patients with COVID-19; Secondary Analysis of an International Multi-Platform RCT

ISTH Academy, Faculty / Presenters, 406174

OC 05.5 Hemostatic Biomarkers in Long-Covid Syndrome: A Cross-Sectional Study of 1,310 Covid-19 Survivors

ISTH Academy, Faculty / Presenters, 406175

OC 15.3 Multiplex Quantitation of Coagulation and Fibrinolysis Markers: An Upcoming Approach to Unravel Bleeding and Thrombotic Disorders

ISTH Academy, Faculty / Presenters, 406176

OC 68.5 Plasma N-Glycan Signatures are Associated with a First Event of Venous Thromboembolism

ISTH Academy, Faculty / Presenters, 406177

OC 57.5 Platelet Aggregation and Transcriptomic Profiling Informs Perioperative Bleeding Risk

ISTH Academy, Faculty / Presenters, 406178

OC 68.3 Plasma Levels of Complement C5 are Associated with Thrombin Generation

ISTH Academy, Faculty / Presenters, 406179

OC 15.2 ROTEM Versus Conventional Coagulation Parameter Based Correction of Coagulopathy in Upper Gastrointestinal Bleed in Cirrhotic Patients-Open Label Randomized Control Trial

ISTH Academy, Faculty / Presenters, 406180

OC 23.3 Naked miRNA Mimics and siRNAs Selectively Transfect Megakaryocytes and Platelets In Vivo and Durably Suppress Target Gene Expression to Modulate Megakaryocyte and Platelet Function in Mice

ISTH Academy, Faculty / Presenters, 406181

OC 23.1 Transfusion of RNA-Edited Platelets in a Rodent Model of Polytrauma: A Pilot Study

ISTH Academy, Faculty / Presenters, 406182

OC 57.1 Peptidomics Reveals Expected and Unexpected Proteolytic Events in Plasma Upon Activation of the Coagulation Cascade

ISTH Academy, Faculty / Presenters, 406183

OC 57.3 Genome-Wide Identification of Loci Controlling Plasma Coagulation Factor IX Activity

ISTH Academy, Faculty / Presenters, 406184

OC 68.4 Elucidating New Prothrombotic Factors by Studying the Associations of Laboratory-Measured D-Dimer with the Circulating Blood Proteome

ISTH Academy, Faculty / Presenters, 406185

OC 57.2 Integrated Proteomic and Computational Approach Reveals Determinants of Bleeding Risk in Factor XI Deficiency

ISTH Academy, Faculty / Presenters, 406186

OC 68.1 Platelet RNA-Sequencing in 393 FraminghamHeart Study Participants Reveals Genetic Regulators for a Third of Expressed Transcripts

ISTH Academy, Faculty / Presenters, 406187

OC 68.2 The Atlas of the Hemostatic RNA-Binding Protein Interactome

ISTH Academy, Faculty / Presenters, 406188

OC 23.5 National External Quality Assessment Scheme (NEQAS BC) and Welsh Blood Service (WBS) use Cold-Stored Platelets for External Quality Assessment (EQA) Scheme for Light Transmission Aggregometry (LTA)

ISTH Academy, Faculty / Presenters, 406189

OC 77.1 Development, Validation, and Implementation of a Decision Support Tool for the Screening of Mild Bleeding Disorders

ISTH Academy, Faculty / Presenters, 406190

OC 77.4 Predicting Bethesda Inhibitor Titers in Hemophilia a Patients on the Basis of Screening Assay Results: Ways to Economize the Bethesda Assay

ISTH Academy, Faculty / Presenters, 406191

OC 23.2 In Vitro Generated Megakaryocytes for the Detection of HPAAlloantibodies in Clinical Samples

ISTH Academy, Faculty / Presenters, 406192

OC 57.4 Deciphering Novel Complex Structural Variations in Severe Hemophilia a Patients by Optical Genome Mapping

ISTH Academy, Faculty / Presenters, 406193

OC 77.5 Development of a Rapid and Fully Automated FVIII Inhibitor Assay Insensitive to the Presence of Emicizumab

ISTH Academy, Faculty / Presenters, 406194

OC 15.1 A Novel Point-of-Care Whole Blood Portable Analyzer for Direct Oral Anticoagulant Monitoring

ISTH Academy, Faculty / Presenters, 406195

OC 77.2 Discrepant Low ACL TOP VWF:GP1bR Result is Frequent in Unselected MPN Patients and Does Not Predict Bleeding Risk

ISTH Academy, Faculty / Presenters, 406196

OC 14.3 A Novel Strategy to Combat the Procoagulant Phenotype in Immune Thrombotic Thrombocytopenia using 12-LoX Inhibition

ISTH Academy, Faculty / Presenters, 406348

PO43 Budd Chiari Syndrome

ISTH Academy, Faculty / Presenters, 407807

PO41 Thrombosis of the Superior Vena Cava

ISTH Academy, Faculty / Presenters, 407808

PO53 Thromboprophylaxis in the Internal Medicine Department at a Public Hospital - Data from 292 Patients from a Single Center in Brazil

ISTH Academy, Faculty / Presenters, 407809

PO36 DOACs for Secondary Prevention of VTE: Yes Indeed!

ISTH Academy, Faculty / Presenters, 407810

PO34 The Risk of Vein Thromboembolism and Prevention in the Critically Illness Facilitated with an Electronic Decision Support System

ISTH Academy, Faculty / Presenters, 407811

PO47 A Vascular Journey

ISTH Academy, Faculty / Presenters, 407812

PO37 Autoimmune Heparin Induced Thrombocytopenia with Thrombosis and Concomitant AIHA Post Orthopedic Surgery - A Case Report

ISTH Academy, Faculty / Presenters, 407813

PO40 Hyperfiltration Syndrome as a Cause of Low Anti-Xa Activity Levels during Enoxaparin Treatment in a Critically Ill Patient

ISTH Academy, Faculty / Presenters, 407814

Issue Information

ISTH Academy, Faculty / Presenters, 408088

Illustrated Abstracts of the 5 EUPLAN International Conference

ISTH Academy, , 408089

A new approach to antiphospholipid antibody syndrome

ISTH Academy, Faculty / Presenters, 408090

Venous thromboembolism prevention in cancer care: implementation strategies to address underuse

ISTH Academy, Faculty / Presenters, 408091

Patient-relevant health outcomes for von Willebrand disease, platelet function disorders, and rare bleeding disorders: a Delphi study

ISTH Academy, Samantha Gouw, 408092

Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial

ISTH Academy, , 408093

Angiopoietin-2 binds to multiple interactive sites within von Willebrand factor

ISTH Academy, , 408094

Surgery in rare bleeding disorders: the prospective MARACHI study

ISTH Academy, MURIEL GIANSILY BLAIZOT, 408095

COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding

ISTH Academy, Faculty / Presenters, 408096

Excluding pregnancy-associated deep vein thrombosis with whole-leg ultrasound

ISTH Academy, Faculty / Presenters, 408097

A thrombus is formed by a gradient of platelet activation and procoagulant endothelium

ISTH Academy, Faculty / Presenters, 408098

Heparin-induced thrombocytopenia in newborns: experience at a pediatric hospital and a literature review

ISTH Academy, Faculty / Presenters, 408099

Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death

ISTH Academy, Faculty / Presenters, 408100

Venous thromboembolism in an Asian COVID-19 cohort across 3 infection waves—a retrospective observational study

ISTH Academy, Faculty / Presenters, 408101

Characterization of copy-number variants in a large cohort of patients with von Willebrand disease reveals a relationship between disrupted regions and disease type

ISTH Academy, Faculty / Presenters, 408102

Quality improvement approaches to heparin-induced thrombocytopenia: a scoping review

ISTH Academy, , 408103

Inhibitors in hemophilia: association with surgery plans and outcomes in a retrospective cohort study

ISTH Academy, Faculty / Presenters, 408104

Heavy menstrual bleeding in adolescents: incidence, diagnostics, and management practices in primary care

ISTH Academy, Faculty / Presenters, 408105

Coagulation profiles during and after anabolic androgenic steroid use: data from the HAARLEM study

ISTH Academy, , 408106

Ethical aspects of hemophilia gene therapy: a qualitative interview study with stakeholders

ISTH Academy, , 408107

Hetrombopag plus recombinant human thrombopoietin for chemotherapy-induced thrombocytopenia in patients with solid tumors

ISTH Academy, , 408108

Acute myocardial infarction in von Willebrand disease: characteristics and outcomes

ISTH Academy, Jeffrey Berger, 408109

Patients with metabolic dysfunction–associated steatotic liver disease have preserved in vitro responses to antiplatelet drugs

ISTH Academy, Ton Lisman, 408110

Preanalytical conditions for multiparameter platelet flow cytometry

ISTH Academy, , 408111

Comparative analysis of Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) scores in persons with nonsevere hemophilia A and B reveals a high degree of joint damage in both disease types

ISTH Academy, Faculty / Presenters, 408112

Heparin monitoring during extracorporeal membrane oxygenation: the effect of dextran sulfate on anti-Xa assay

ISTH Academy, Faculty / Presenters, 408113

New insights into the diagnosis and management of patients with type 2M von Willebrand disease

ISTH Academy, , 408114

Use of nonacog beta pegol during surgery in persons with hemophilia B: a case series

ISTH Academy, Faculty / Presenters, 408115

Cangrelor for cardiopulmonary bypass in delayed-onset heparin-induced thrombocytopenia: a case report

ISTH Academy, Faculty / Presenters, 408116

Trisomy X conferring moderate hemophilia A by extremely skewed X-chromosome inactivation

ISTH Academy, , 408117

Long-term risk of venous thromboembolism after COVID-19 mainly related to intensive care unit stay based on findings of a self-controlled case series study

ISTH Academy, , 408118