PB1387 Frequency of Inherited Platelet Secretion Disorders in Patients Referred to the Special Coagulation Laboratory of the Iranian Blood Transfusion Organization (IBTO)

ISTH Academy, Faculty / Presenters, 407330

PB1388 Sticky Platelet Syndrome: Clinical Experience from a Tertiary Center

ISTH Academy, Faculty / Presenters, 407331

PB1382 Inherited Platelet Function Disorder in Pediatric Patient with Identified CalDAG-GEFI Deficiency

ISTH Academy, Faculty / Presenters, 407332

PB1383 RUNX1-Mutated Familial Platelet Disorder (RUNX1-FPD) with Associated Acute Myeloid Leukaemia - A Case/Family Series

ISTH Academy, Faculty / Presenters, 407333

PB1384 Survey on Functional and Molecular Characterization of Inherited Platelet Disorders in Spain

ISTH Academy, Faculty / Presenters, 407334

PB1381 Value of Next-Generation Sequencing in the Diagnosis of Platelet Function Disorders

ISTH Academy, Faculty / Presenters, 407335

PB1378 Complex Phenotypic Expression of an ADP Receptor (P2Y12) Defect in Greater Swiss Mountain Dogs

ISTH Academy, Faculty / Presenters, 407336

PB1379 Utility of Platelet Activation Marker PAC-1 for Identification of Functional aIIbβ3 Integrin Defects in Glanzmann Thrombasthenia Variants by Flow Cytometry

ISTH Academy, Faculty / Presenters, 407337

PB1377 Living with Glanzmann's Thrombasthenia: An Interim Report from the Glanzmann's 360 International Patient Survey

ISTH Academy, Faculty / Presenters, 407338

PB1376 Periprocedural Hemostatic Outcomes in Bleeding of Unknown Cause

ISTH Academy, Faculty / Presenters, 407339

PB1375 Menstrual Bleeding in Women with Glanzmanns Thombasthenia - Results from the Glanzmanns 360 Study (GT360)

ISTH Academy, Faculty / Presenters, 407340

PB1374 Anti-ɑIIbβ3 Antibodies in Glanzmann Thrombasthenia Patients may Generate Procoagulant Platelets by Complement Activation

ISTH Academy, Faculty / Presenters, 407341

PB0821 Multimer Analysis of von Willebrand Factor in von Willebrand Disease with a Hydrasys Semi-Automatic Analyzer

ISTH Academy, Faculty / Presenters, 407342

PB0820 In Silico Evidence of the Conformational Transitions Associated with the p.R854Q Mutation in the D'D3 Domain of von Willebrand Factor, Responsible for Its Weakened FVIII Interaction

ISTH Academy, Faculty / Presenters, 407343

PB0819 Quantification of von Willebrand Factor Proteoforms by Mass Spectrometry-Based Proteomics Reveals Differential Variant-to-Wild Type Stoichiometry in Subtypes of von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407344

PB0818 Impact of ABO Blood Group Genotype on VWF Level in Carriers of Type 3 von Willebrand Disease from the French von Willebrand Disease Reference Center

ISTH Academy, Faculty / Presenters, 407345

PB0814 Endothelial Cells, Not Blood, Dictate Where, When, and How Hemostasis Initiates under Flow Conditions: Mechanistic Studies Using a Vascularized Hemostasis-on-a-Chip System

ISTH Academy, Faculty / Presenters, 407346

PB0815 Involvement of the Nuclear Protein, TC2N, in Regulating VWF Levels in Endothelial Cells

ISTH Academy, Faculty / Presenters, 407347

PB0816 Phenotypic Characterization of von Willebrand Disease Type 3 Patient-Derived ECFCs with a Homozygous p.M771V Mutation

ISTH Academy, Faculty / Presenters, 407348

PB0810 Investigating ADAMTS13 Cleavage of von Willebrand Factor under Flow

ISTH Academy, Faculty / Presenters, 407349

PB0817 Proximity Biotinylation Proteomics to Identify Novel Regulators of Weibel-Palade Body Morphology and von Willebrand Factor Secretion

ISTH Academy, Faculty / Presenters, 407350

PB0811 Natural Variants of von Willebrand Factor R1205 Associated with Type 1 von Willebrand Disease: In-Silico Docking Models and Energetics of the Interactions with the Macrophagic Scavenger Receptor LRP1

ISTH Academy, Faculty / Presenters, 407351

PB0812 The Importance of the Amino-Acid Residue at Position 2561 in the C4-Domain of von Willebrand Factor

ISTH Academy, Faculty / Presenters, 407352

PB0813 Using Flow Assays to Probe von Willebrand Factor Function

ISTH Academy, Faculty / Presenters, 407353

PB0809 Transcriptional Coactivators YAP and TAZ Contribute Differently to the Transcriptional Regulation of VWF in Venous and Arterial Endothelial Cells

ISTH Academy, Faculty / Presenters, 407354

PB0808 Localized Endothelial Colony-Forming Cell-Derived von Willebrand Factor (VWF) Influences In Vivo Angiogenesis in VWF-Deficient Mice

ISTH Academy, Faculty / Presenters, 407355

PB0807 The Small, Dense Fraction of Low-Density Lipoprotein (LDL) is the Only Plasma Lipoprotein Capable of Enhancing von Willebrand Factor (VWF) Self-Association

ISTH Academy, Faculty / Presenters, 407356

PB0860 Von Willebrand Factor is an Independent Predictor of Short-Term Mortality in Acutely Ill Patients with Cirrhosis

ISTH Academy, Faculty / Presenters, 407357

PB0858 Evaluation of Automated Chemiluminescent von Willebrand Factor Assays in the Diagnosis of von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407358

PB0852 Abnormal von Willebrand Factor Test in Patients with Extreme Thrombocytosis

ISTH Academy, Faculty / Presenters, 407359

PB0853 Comparison of VWF:RCo/VWF:Ag Ratios with the VWF Large Multimer Indices in Patients with Aortic Stenosis

ISTH Academy, Faculty / Presenters, 407360

PB0854 Could Gynecologists Contribute to an Increased Diagnosis of von Willebrand Disease among Women with Heavy Menstrual Bleeding?

ISTH Academy, Faculty / Presenters, 407361

PB0855 New Mutation in CK Domain of VWF Gene in Patient with Type 2N von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407362

PB0856 Time Course of Thrombocytopenia during DDAVP Test in a Boy with a De Novo c.4121G>A ( p.Arg1374His) Variant of the VWF Gene

ISTH Academy, Faculty / Presenters, 407363

PB0847 DDAVP-Trial has a Possible Role for Auxiliary Diagnosis in Type 1 and Type 2 von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407364

PB0848 Differences between Collagen-6 Binding and Collagen-1 Binding in Type-2 VWD (Preliminary Study)

ISTH Academy, Faculty / Presenters, 407365

PB0849 Importance of VWF:CB Assay in Diagnosis of 2M VWD

ISTH Academy, Faculty / Presenters, 407366

PB0850 Management of Type 2M von Willebrand Disease in Lower Limb Surgery

ISTH Academy, Faculty / Presenters, 407367

PB0844 Assessment of the De Novo Origin of the p.Val1316Met Mutation in Four Unrelated Patients with Type 2B von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407368

PB0845 Healthcare Resource Utilization in Patients with von Willebrand Disease Receiving Recombinant von Willebrand Factor on Demand and in Surgical Settings: Results from a European Chart Review

ISTH Academy, Faculty / Presenters, 407369

PB0846 Membrane Procoagulation and N-Terminomics/TAILS Profiling in Montreal Platelet Syndrome Kindred with VWF p.V1316M Mutation

ISTH Academy, Faculty / Presenters, 407370

PB0837 Analysis of the Change in Diagnosis of von Willebrand Disease by Region and Economic Status

ISTH Academy, Faculty / Presenters, 407371

PB0838 Association between Hemoglobin Values and VWF Assays: A Multi-Center Investigation

ISTH Academy, Faculty / Presenters, 407372

PB0840 Efficacy of Prophylaxis with a Plasma-Derived von Willebrand Factor/ Factor VIII Concentrate in Patients with von Willebrand Disease: Subgroup Analysis by Age and VWD Type

ISTH Academy, Faculty / Presenters, 407373

PB0841 Investigation of VWD in Women with Menorrhagia or Dysmenorrhea Associated with Bleeding

ISTH Academy, Faculty / Presenters, 407374

PB0842 Surgical and Procedural Outcomes in Pediatric Patients with Mild Type 1 von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407375

PB0843 The Alarming Persistence of Heavy Menstrual Bleeding in Persons with Inherited Bleeding Disorders Managed in Hemophilia Treatment Centers

ISTH Academy, Faculty / Presenters, 407376

PB0834 Antiplatelet Use and Outcomes among Patients with Acute Coronary Syndrome and von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407377

PB0835 Comparison of Bleeding Symptoms and Global Haemostatic Tests (ROTEM and Clot Wave Form Analysis) in Type 3 VWD and Mild/ Moderate Haemophilia A with Similar Levels of Factor VIII

ISTH Academy, Faculty / Presenters, 407378

PB0836 Functional Analysis of Four Novel von Willebrand Disease Causing Mutations

ISTH Academy, Faculty / Presenters, 407379

PB0830 Inspecting Underlying Pathogenesis Mechanisms of Von Willebrand Disease Variants Sited in A Domains of the von Willebrand Factor

ISTH Academy, Faculty / Presenters, 407380

PB0833 VWF Expression Mostly Confirms Genetic Prediction Algorithms in Type 1 VWD Variants

ISTH Academy, Faculty / Presenters, 407381

PB0831 Novel VWF Exon 9-10 Duplication in a Family with Inherited Bleeding, High VWF:Ag and FVIII Levels, and Loss of High Molecular Weight VWF Multimers

ISTH Academy, Faculty / Presenters, 407382

PB0832 Optimizing Treatment of Pregnant Women with von Willebrand Disease: A Retrospective Analysis of Factor Replacement Therapy during Delivery

ISTH Academy, Faculty / Presenters, 407383

PB0829 Defining the Impact of Ageing on ISTH-BAT (ISTH-SSC Endorsed Bleeding Assessment Tool) Scores in Women With Low von Willebrand Factor (VWF) Levels

ISTH Academy, Faculty / Presenters, 407384

PB0828 A Novel VWF Platelet-Dependent Assay that Differentiates GPIbα- Binding Activity in Multimers of Different Sizes

ISTH Academy, Faculty / Presenters, 407385

PB0825 Effect of von Willbrand Factor Concentrate on von Willebrand Factor Parameters during ECMO

ISTH Academy, Faculty / Presenters, 407386

PB0826 Examining Plasma von Willebrand Factor (VWF) Thresholds to Reduce Repeated VWF Testing in Adults

ISTH Academy, Faculty / Presenters, 407387

PB0827 WFH World Bleeding Disorders Registry Launches the First Global Data Collection on People with von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407388

PB0824 Prospective Longitudinal Evaluation Shows Increase of VWF and FVIII Activity with Age in Patients with Type 1 and 2 von Willebrand Disease

ISTH Academy, Faculty / Presenters, 407389

PB0387 Characterising the Molecular Pathways Controlled by ETV6 during Megakaryopoiesis

ISTH Academy, Faculty / Presenters, 407390

PB0386 Increased Platelet Expression of the Transcriptional Suppressor ETV6 Can Be Detected by Immunofluorescence on the Blood Smear and Associates with ETV6-Related Thrombocytopenia

ISTH Academy, Faculty / Presenters, 407391

PB0384 Spatiotemporal Evolution of Mammalian Megakaryocytes during Ontogeny

ISTH Academy, Faculty / Presenters, 407392

PB0385 Systemic Lupus Erythematosus-Induced Amegakaryocytic Thrombocytopenia and Subsequent Aplastic Anemia

ISTH Academy, Faculty / Presenters, 407393

PB0380 Corrections of Bernard Soulier Syndrome Megakaryocyte Phenotypes by Small Molecules and Interleukin-1α

ISTH Academy, Faculty / Presenters, 407394

PB0381 Red Blood Cell Inclusions of Non-Muscle Myosin IIA Associate with GATA1-Related Thrombocytopenia

ISTH Academy, Faculty / Presenters, 407395

PB0377 Analysis of Hepatic TPO Production after Myocardial Infarction and Partial Hepatectomy

ISTH Academy, Faculty / Presenters, 407396

PB0378 DNA Damage Accumulation in Polyploid Megakaryocytes: Investigating the Impact of Poly (ADP-ribose) Polymerase (PARP) Inhibitors

ISTH Academy, Faculty / Presenters, 407397

PB0379 Study of Megakaryocytes in Systemic Lupus Erythematosus

ISTH Academy, Faculty / Presenters, 407398

PB0375 Changes in Platelet Size Induced by Treatment in Patients with Myeloproliferative Neoplasms. Cytoskeletal Study during Platelet Production

ISTH Academy, Faculty / Presenters, 407399

PB0376 Vacuolar-Type ATPase Dependent Acidification of Megakaryocyte and Platelet α-Granules Maintains Packaging of VWF

ISTH Academy, Faculty / Presenters, 407400

PB0373 Increased Megakaryopoiesis and Thrombopoiesis Induced by Plasma from Myelofibrosis and Essential Thrombocythemia Patients

ISTH Academy, Faculty / Presenters, 407401

PB0374 JAM-A Regulates Zipper-Like Structures That Are Essential for Maintaining the Integrity of Megakaryocytes

ISTH Academy, Faculty / Presenters, 407402

PB0368 Development and First Human Transfusion of Allogeneic iPSC- Derived Platelet Product (MEG-002)

ISTH Academy, Faculty / Presenters, 407403

PB0369 New Insights into the Formation of Platelets (Thrombopoiesis) from Infused Megakaryocytes (Mks) into Mice

ISTH Academy, Faculty / Presenters, 407404

PB0915 Desialylation of Platelet Induced by Neuraminidase Accelerates Platelet Aggregation and Activation

ISTH Academy, Faculty / Presenters, 407405

PB0913 Desialylated Platelets are Involved in the Proliferation of HepG2 Cells

ISTH Academy, Faculty / Presenters, 407406

PB0910 Evaluation of the Clot Formation Tranfusing Fresh, Cold and Frozen Platelets. Advantages for the Military Environment

ISTH Academy, Faculty / Presenters, 407407

PB0911 Platelet Reactivity in Patients with Atrial Fibrillation and Coronary Artery Disease under IIa Antagonists and Xa Antagonists

ISTH Academy, Faculty / Presenters, 407408

PB0912 Study to Determine the Minimum Number of Platelet Events Acquisition Required for Flow Cytometry based Platelet Function Testing in Healthy Controls and Patients with Thrombocytopenia

ISTH Academy, Faculty / Presenters, 407409

PB0904 A Novel Quantitative Flow Cytometry Approach in Determining Platelet Subpopulations and Quantifying Cell Surface Receptors

ISTH Academy, Faculty / Presenters, 407410

PB0905 Assessment of Therapeutic Window for Antiplatelet Taking Cardiology Patients: Anysis-P2Y12 Assay

ISTH Academy, Faculty / Presenters, 407411

PB0906 Modified Platelet Storage Devices to Improve Quality during Storagee

ISTH Academy, Faculty / Presenters, 407412

PB0907 Study to Determine the Effects of Pneumatic Chute System Transport on Biophysical Properties and Functional Activity of Platelet Concentrates

ISTH Academy, Faculty / Presenters, 407413

PB0908 Therapeutic Efficacy of Platelet-Rich Plasma in Chronic Compression of the Dorsal Root Ganglion in Rat

ISTH Academy, Faculty / Presenters, 407414

PB0909 TREM-Like Transcript-1, a Platelet Receptor, as a Potential Regulator of Hepatic Regeneration Post-Surgical Resection

ISTH Academy, Faculty / Presenters, 407415

PB0898 Comparative Methods of Platelet Aggregation by Light Transmission in Elderly Patients

ISTH Academy, Faculty / Presenters, 407416

PB0899 Connexin 45 is Co-Localized with Coxsackievirus-Adenovirus Receptor Forming Contact Membrane within Platelet Aggregates and Filopodia

ISTH Academy, Faculty / Presenters, 407417

PB0900 Developing Standards to Support Platelets and Platelet Components

ISTH Academy, Faculty / Presenters, 407418

PB0902 The Effect of Hypercortisolism on Platelet Function in Dogs with Cushing's Syndrome

ISTH Academy, Faculty / Presenters, 407419

PB0895 Platelet Activation and Aggregation Assays in Non-Human Primates for the Evaluation of Potential Effects of New Drugs in the Context of Non-Clinical Studies

ISTH Academy, Faculty / Presenters, 407420

PB0896 Time-and Distance-Resolved Robotic Imaging of Fluid Flow in Vertical Microfluidic Strips: A New Technique for Quantitative, Multiparameter Global Measure of Haemostasis

ISTH Academy, Faculty / Presenters, 407421

PB0892 C-3399 Inhibitor of PDI Isoforms with an Attractive Profile of Antiplatelet Action

ISTH Academy, Faculty / Presenters, 407422

PB0893 Characterization of the TLT-1 Fibrinogen Ligand Interaction

ISTH Academy, Faculty / Presenters, 407423

PB0894 Evaluating Platelet Function Post Transfusion with Cold-Stored vs Room Temperature Platelets in Patients with Traumatic Brain Injury

ISTH Academy, Faculty / Presenters, 407424

PB0889 Biodesigned Recombinant Protein Mimicking Activities of Fibrillar Collagen in Primary Haemostasis

ISTH Academy, Faculty / Presenters, 407425

PB0890 Discrimination of Agonists-Stimulated Platelet Phenotypes Depending on Pathogen Inactivation and Storage Temperature in a Blood Bank

ISTH Academy, Faculty / Presenters, 407426

PB0891 Impact of Enhanced Platelet Turnover on Platelet Reactivity in Healthy Humans

ISTH Academy, Faculty / Presenters, 407427

PB0882 Contractility of Megakaryocytes and Platelets: Similarities and Distinctions

ISTH Academy, Faculty / Presenters, 407428

PB0883 Defining the Role of Hepcidin and Ferroportin Interactions in Regulating Platelet Function

ISTH Academy, Faculty / Presenters, 407429