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This live session was hosted on:
May 27, 2022  14:30-15:30 UTC



Session Description:
This webinar will feature talks by Prof. Mettine Bos and Dr. Laurent Mosnier on their exciting research on mutants of hemostatic proteins as potential therapeutics.  



Event Outline:


  • Introduction by Dr. Colin Kretz
  • Engineering of Activated Factor V as Therapy for Severe Bleeding - Super Factor Va- Laurent Mosnier, Ph.D. (~20 minutes)
  • Recombinant Factor X Variants as DOAC Antidotes - from Snake Venom to Therapeutic Protein- Mettine Bos, Ph.D. (~20 minutes)
  • Q&A with audience (15 minutes)
Learning Objectives:



Engineering of Activated Factor V as Therapy for Severe Bleeding - Super Factor Va
  • Understanding different mechanisms that can contribute to bleeding in settings of Hemophilia, DOACs, and Acute Traumatic Coagulopathy (ATC)
  • Learn how engineering of activated Factor V can target the different mechanisms that contribute to bleeding
Recombinant Factor X Variants as DOAC Antidotes - from Snake Venom to Therapeutic Protein
  • Understand the biochemistry and mechanism of action of modifications in factor X(a) to overcome inhibition by factor Xa-inhibiting direct oral anticoagulants
  • Learn how a snake venom toxin can form the basis for a factor X-based bypassing agent with therapeutic potential


This webinar is free for full ISTH members and $25 USD for Academy members. Academy membership and student membership is free, and other membership rates are as low as $35 USD. Learn more about membership and join today here

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