| 6. Specializing Testing for Thrombotic Disorders |
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6.2: Identify the limitations (e.g. strengths, weaknesses) of specialized testing for thrombotic disorders.
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6.3 Formulate follow-up testing as appropriate based on the results of specialized testing for initial and recurrent thrombotic events
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6.4 Interpret functional and genetic tests used for the diagnosis of acquired and congenital inhibitor deficiencies (e.g. antithrombin, protein C, Protein S, tissue factor pathway inhibitor)
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6.5 Perform functional and genetic testing of congenital and acquired prothrombotic factors (e.g. FV Leiden, Prothrombin G20210A, JAK2)
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6.6 Interpret functional and genetic testing of congenital and acquired prothrombotic factors
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6.7 Perform and interpret laboratory tests used for the diagnosis of the antiphospholipid syndrome
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6.8 Perform and interpret laboratory tests used for the therapeutic monitoring in patients taking vitamin K antagonists, heparins, antiplatelet drugs and DOACs
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6.9 Apply knowledge on the use and limitations of tests for activated coagulation status (e.g. D-Dimer, prothrombin fragment 1+2, Thrombin-Antithrombin complex)
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6.10 Apply understanding fo the function, limitations and applications of global tests for thrombotic and fibrinolytic disorders (e.g. thromboelastography/-metry, thrombin generation)
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6.11 Perform and interpret laboratory tests for the assessment of the fibrinolytic system (e.g. plasminogen, plasminogen activator inhibitor-1, alpha-2-antiplasmin, thrombin activatable fibrinolysis inhibitor), and for monitoring fibrinolytic therapy
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6.12 Apply knowledge of new developments (e.g. Flow-based systems, flow cytometry, to diagnostic practice in thrombosis and hemostasis)
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