ISTH Academy

Create Account Sign In
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
Author(s):
Ning Tang
,
Ning Tang
Affiliations:
Dengju Li
,
Dengju Li
Affiliations:
Xiong Wang
,
Xiong Wang
Affiliations:
Ziyong Sun
Affiliations:
Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Ziyong Sun, Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
ISTH Academy. Sun Z. 02/19/20; 290504
Ziyong Sun
Ziyong Sun
Contributions
Journal Abstract
Background
In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.
Objectives
To describe the coagulation feature of patients with NCP.
Methods
Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.
Results
The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non‐survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.
Conclusions
The present study shows that abnormal coagulation results, especially markedly elevated D‐dimer and FDP are common in deaths with NCP.

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies