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Program Overview

This section of the ISTH Clinical Core Curriculum deals with aspects of haemophilia A and B to attain a level of proficiency to enable them to practice independently as specialists in the field.

Self needs-assessment questions
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Apply their understanding of the epidemiology and molecular basis of haemophilia to clinical management of patients with this disorder
Relate the impact of the history of haemophilia and the evolution of replacement therapy to issues relating to clinical management of patients affected by haemophilia
Relate the principles of the structural and functional aspects of the biology of factor VIII (FVIII) and factor IX (FIX) to clinical management of patients with haemophilia A or B
Recognize clinical manifestations of haemophilia
Diagnose haemophilia A and B by interpreting laboratory tests
Perform laboratory tests for diagnosis of haemophilia A and B
Provide haemophilia treatment such as delivery of replacement therapy (primary and secondary prophylaxis, on-demand therapy of bleeds)
Relate the principles of the epidemiology, immunology and molecular basis of inhibitors to FVIII, or FIX to clinical management of patients with haemophilia A or B
Diagnose patients with inhibitors to FVIII and FIX by interpreting laboratory tests
Perform laboratory tests for inhibitors to FVIII and FIX
Manage patients with inhibitors to FVIII and FIX
Manage dosing regimens for immune tolerance induction in patients with inhibitors, as well as in the use of immunosuppressive drugs, apheresis and immunoadsorption
Provide management plans for peri-operative haemostatic support in patients with haemophilia requiring surgery
Provide management plans for dental procedures in patients with haemophilia
Provide management plans for physiotherapists for prevention and treatment of arthropathy in haemophilia patients
Provide advice for management of haemostasis in symptomatic carriers of haemophilia A and B requiring surgery
Manage issues relating to transfusion-transmitted diseases especially HIV and HCV in patients with bleeding disorders in collaboration with appropriate specialists
Apply their understanding of gene therapy and molecular engineering of FVIII and FIX to clinical management of patients with haemophilia A and B
Appreciate the issues relating to the provision of haemophilia care in different parts of the world and the difficulties of providing diagnostic and therapeutic services in some countries
Provide a comprehensive care service for patients with haemophilia
Final self-assessment & evaluation
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